The entropic view of aging: from thermodynamics to biology

Clicks: 54
ID: 315008
2026
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Ranked #6 of 18 articles by views in Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

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Abstract
Abstract A growing body of evidence suggests that aging is not simply the accumulation of damage, but a systemic progression of increasing entropy across biological scales. Synthesizing concepts from thermodynamics and information theory, we propose a three-stage entropy model of the lifespan: order-building development, homeostatic adulthood, and disorder-dominant aging. Within this model, we reframe the established hallmarks of aging as interconnected nodes in an entropy-centered network and detail the multiscale manifestations of disorder from molecules to systems. To quantify this trajectory, we introduce a Multiscale Entropic Aging Index (MEAI) as a proof-of-concept conceptual framework, designed to integrate measurements of disorder across biological levels. This framework offers a potential unifying, quantitative language for aging research and positions entropy reduction as a testable mechanism underlying interventions, laying a principled foundation for the future development of biomarkers and rejuvenative strategies.
Reference Key
openalex_W7162427714 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zeming Wu, Si Wang, Moshi Song, Wei Zhang, Jing Qu, J C Izpisua Belmonte, Guang-Hui Liu
Journal Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
Year 2026
DOI
10.1093/lifemedi/lnag020
URL
https://doi.org/10.1093/lifemedi/lnag020
Keywords Keywords not found

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