Dual-faceted regulation by Butyrophilin 1A1 to produce MUC5AC and IL-8 from human colonic cell line HT29-MTX-E12

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ID: 314781
2026
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Abstract
Abstract Butyrophilin subfamily 1 member A1 (BTN1A1) is a major protein of the milk fat globule membrane, but its immunoregulatory function remains largely unresolved, despite its structural similarity to the B7 co-stimulatory molecules. In this study, we investigated the immunological significance of BTN1A1 in gastrointestinal epithelial cells. The human ectodomain of BTN1A1 expressed as a soluble Fc fusion protein (ectoBTN-Fc) was added to HT29-MTX-E12 cells as a model for gastrointestinal epithelial cells. In the absence of TNF-α, it significantly promoted MUC5AC production via a weak activation of NF-κB signal transduction pathway. In contrast, prior incubation with ectoBTN-Fc inhibited TNF-α-provoked-IL-8 secretion by suppressing the phosphorylation of NF-κB p65. Binding analyses demonstrated that ectoBTN-Fc likely binds to HT29-MTX-E12 cells, followed by its endocytosis. These results suggest a dual-faceted regulatory function of BTN1A1. It reinforces intestinal mucosal barrier function under basal conditions, while it may endow a prophylactic effect alleviating strong inflammatory stimulation.
Reference Key
openalex_W7162210469 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Minori Ishida, Yuki Kuwana, Mizuki Tsujimoto, Hyejin Namgung, 古江文美, Fumito Tani
Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag072
URL
https://doi.org/10.1093/bbb/zbag072
Keywords Keywords not found

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