Lipid Chain Length-dependent Anchoring of Artificial Lipidated Proteins Enables Cell-Selective Uptake of Extracellular Vesicles

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ID: 314774
2026
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Abstract
Abstract Extracellular vesicles (EVs) are promising drug delivery carriers; however, systematic and minimally invasive strategies for EV surface protein display remain limited. Here, we report a modular approach based on microbial transglutaminase-mediated site-specific lipidation to prepare molecularly uniform lipid–protein conjugates with precisely defined alkyl chain lengths. Quantitative analysis revealed lipid chain length-dependent EV membrane anchoring. Extension to a human epidermal growth factor receptor (HER2)-targeting affibody enabled selective EV uptake modulation, enhancing internalization in HER2-positive cells while suppressing nonspecific uptake in HER2-negative cells. This strategy provides a tunable platform for rational EV surface engineering.
Reference Key
openalex_W7162217316 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nozomu Ogushi, Kazuki Uchida, Yoshirou Kawaguchi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya
Journal phytochemistry letters
Year 2026
DOI
10.1093/chemle/upag092
URL
https://doi.org/10.1093/chemle/upag092
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