Baroreceptor Sensitivity as an Independent Predictor for Functional Outcomes in Acute Ischemic Stroke

Clicks: 2
ID: 314718
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #52 of 112 articles by views in qjm : monthly journal of the association of physicians

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Post-stroke autonomic dysfunction is a critical determinant of long-term prognosis. Reduced baroreceptor sensitivity (BRS), a marker of this dysfunction, has been linked to adverse outcomes, but its independent predictive value for functional recovery requires clarification. Aim To evaluate the independent prognostic value of BRS measured in the acute phase of a first-ever ischemic stroke for predicting 12-month functional outcomes. Design A prospective, single-center, observational cohort study. Methods We enrolled 292 patients with a first-ever acute ischemic stroke. BRS was measured within 7 days of onset, typically between days 4 and 7, using the sequence method under standardized conditions. Patients were dichotomized into low-BRS (≤11 ms/mmHg) and high-BRS groups. The primary endpoint was 12-month functional outcome, assessed by the modified Rankin Scale (mRS) and Barthel Index (BI). We used inverse probability of treatment weighting (IPTW) and multiple logistic regression to assess the independent association between BRS and outcomes. Results After adjustment, low BRS remained a significant independent predictor of poor 12-month outcomes. Patients in the low-BRS group had more than double the adjusted odds of an unfavorable outcome (mRS 3–6; adjusted OR 2.06, 95% CI 1.12–3.78) and more than triple the adjusted odds of moderate-to-severe dependency (BI ≤ 90; adjusted OR 3.13, 95% CI 1.63–6.00) compared with the high-BRS group. Conclusions Reduced BRS in the acute phase of ischemic stroke was independently associated with poor 12-month functional outcomes. If confirmed in external cohorts and implemented with standardized protocols, BRS assessment may help early risk stratification after stroke.
Reference Key
openalex_W7162146010 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cheng-Chang Yen, Hsin-Hung Chen, Po-Ming Chen, Yu-He Li, Ching‐Huang Lin
Journal qjm : monthly journal of the association of physicians
Year 2026
DOI
10.1093/qjmed/hcag131
URL
https://doi.org/10.1093/qjmed/hcag131
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.