PPARγ-dependent transcriptional regulation of Vaspin expression in adipocytes

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ID: 314535
2026
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Abstract
Vaspin is an adipokine involved in metabolic regulation; however, the mechanisms governing its transcription in obesity remain unclear. Here, we investigated the role of peroxisome proliferator-activated receptor γ (PPARγ) in regulating Vaspin expression in white adipose tissue (WAT). Vaspin expression was markedly reduced in the WAT of obese ob/ob mice and was restored following rosiglitazone treatment. Reporter assays revealed that ligand-activated PPARγ promotes Vaspin transcription through a weak but functional PPAR response element (PPRE). Promoter deletion analysis further showed that this PPRE contributes to transcriptional activation, whereas additional promoter regions containing C/EBP-responsive elements sustain residual transcriptional activity. These findings suggest that Vaspin expression is regulated, at least partly, through a non-canonical PPARγ-dependent mechanism involving cooperative transcriptional regulation. Our findings provide insight into adipokine regulation in obesity and highlight gene-specific differences in PPARγ-mediated transcription.
Reference Key
openalex_W7162039854 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Daisuke Aibara, Kimihiko Matsusue
Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag073
URL
https://doi.org/10.1093/bbb/zbag073
Keywords Keywords not found

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