Randomized Phase 2b Trial of CBL-514 Injection for Abdominal Subcutaneous Fat Reduction With Clinician- and Patient-reported Outcomes and MRI Assessment
Clicks: 2
ID: 314275
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.3
/100
2 views
1 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #66 of 73 articles by views in Aesthetic surgery journal
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
BACKGROUND: CBL-514, a small-molecule injectable lipolysis agent that induces adipocyte apoptosis, demonstrated clinically meaningful reductions in abdominal subcutaneous fat by ultrasound in previous Phase 2 studies, with no observed necrosis or nerve injury. OBJECTIVES: To evaluate the efficacy and safety of CBL-514 for abdominal subcutaneous fat reduction using clinician-reported scale, patient-reported scale, and MRI assessments. METHODS: In this randomized, single-blind, placebo-controlled Phase 2b trial (NCT05736107), 108 adults with moderate (Grade 3) to severe (Grade 4) abdominal subcutaneous fat were randomized 1:1 to receive up to four CBL-514 (2 mg/cm2; ≤600 mg/treatment) or placebo treatments at 3-week intervals). Primary efficacy was the proportion of participants with ≥1-grade improvement on the Clinician-Reported Abdominal Fat Rating Scale (CR-AFRS) at 12-week follow-up. Secondary endpoints included Patient-Reported AFRS (PR-AFRS), MRI-assessed changes in abdominal fat volume and thickness, and safety. RESULTS: In the full analysis set, 76.7% (23/30) of CBL-514-treated participants achieved ≥1-grade CR-AFRS improvement versus 18.9% (7/37) with placebo (P<0.0001). PR-AFRS results were similar, with 76.7% (23/30) of CBL-514 participants achieving ≥1-grade improvement versus 19.4% (7/36) in placebo (P<0.0001). MRI demonstrated least squares (LS) mean abdominal fat volume reduction compared to baseline of -152.9 mL ± 17.75, with LS mean percent changes of -20.3%, both significantly greater than placebo (P<0.0001). Most responders demonstrated improvement on the CR-AFRS after 1-2 treatments. CBL-514 was well tolerated, with mainly mild, transient injection-site reactions. CONCLUSIONS: CBL-514 significantly reduced abdominal fat by patient- and clinician-reported outcomes and MRI, with a favorable safety profile supporting its potential as a minimally invasive option.
| Reference Key |
openalex_W7161837307
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Z Paul Lorenc, M. Gold, Joel Schlessinger, Edward (Ted) Lain, Stacy Smith, Jeanine Downie, Sue Ellen Cox, Yu-Fang Ling, An-Yi Sheu, Chih-Yun Lu, Y.-P. Chou |
| Journal | Aesthetic surgery journal |
| Year | 2026 |
| DOI |
10.1093/asj/sjag092
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.