Cortical subpial aging-related tau astrogliopathy in older adult men who participated in youth amateur American-style football
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ID: 314272
2026
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Abstract
Astrocytes play essential roles in various functions including ionic homeostasis, energy metabolism, neurotransmission, and regulation of the blood-brain barrier. Researchers have reported that hyperphosphorylated tau in astrocytes can be identified in postmortem, particularly in individuals over the age of 60 years. Astrocytic p-tau has also been reported in association with chronic traumatic encephalopathy neuropathologic change (CTE-NC). This study investigates possible association between subpial aging-related tau astrogliopathy (ARTAG) and a history of playing high school American-style football. Postmortem brain tissue samples were obtained from 176 men (median age at death = 65 years; range = 50-96) from the Lieber Institute for Brain Development. There were 128 with no known history of participating in contact or collision sports and 48 (27.3%) who participated in football. Subpial ARTAG was identified in 23 cases (13.1%). Those who participated in football had a higher percentage with subpial ARTAG than those who did not participate in football (20.8% vs 10.2%), although this difference was not statistically significant (P =.061). The 2 groups did not differ in the percentages who had subpial ARTAG in a sulcal depth (10.4% of former football players and 7.8% of controls). More research is needed to understand possible associations between subpial ARTAG, aging, and CTE-NC.
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| Authors | Grant L Iverson, Pouya Jamshidi, Amy Deep‐Soboslay, Thomas M Hyde, Joel E Kleinman, Claire E. Shepherd, Lili‐Naz Hazrati, Rudolph J Castellani |
| Journal | Journal of Neuropathology & Experimental Neurology |
| Year | 2026 |
| DOI |
10.1093/jnen/nlag032
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| URL | |
| Keywords | Keywords not found |
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