The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats

Clicks: 3
ID: 314207
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #887 of 1,217 articles by views in Nucleic Acids Research

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,217 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Nuclear pore complexes (NPCs) mediate selective transport between the nucleus and the cytoplasm but also contribute to maintaining genome stability. Mutations in NPC genes cause genome instability and sensitivity to DNA-damaging agents, and DNA that is difficult to repair or replicate relocates to NPCs, including expanded CAG repeats, which are associated with several neurological diseases. Here, we show that other disease-related short tandem repeats also relocate to NPCs. Relocation depends on the NPC basket protein Nup1, but is independent of the rest of the basket. Abrogating relocation to the NPC increases rates of repeat contraction, but not expansion. By contrast, deletion of the basket component NUP60, which causes mislocalization of all other basket proteins except Nup1, results in greater sensitivity to DNA-damaging agents and a higher rate of gross chromosomal rearrangement without affecting relocation to NPCs. Our results show that NPC association is a general feature of disease-related short tandem repeats, and suggest that relocation to NPCs is separable from the other genome maintenance functions of the NPC basket.
Reference Key
openalex_W7161767129 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sandra Ollivaud, Daniele Novarina, Elizabeth C Riquelme Barrientos, Hinke G. Kazemier, Suzan Gonera, Maxime Kislanski, Liesbeth M. Veenhoff, Michael Chang
Journal Nucleic Acids Research
Year 2026
DOI
10.1093/nar/gkag496
URL
https://doi.org/10.1093/nar/gkag496
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.