Bacterial quorum sensing systems in cell-cell communication

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ID: 313850
2026
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Abstract
Antimicrobial resistance and the emergence of multi-drug-resistant pathogens necessitate holistic care. Novel antimicrobial drug discovery involves an in-depth assessment of quorum sensing (QS) signaling and cell-cell communication. Bacteria regulate their metabolism to cope with complex host-environmental changes through QS signaling. Previous studies suggest that the social behaviors of bacteria include biofilm formation, virulence, and drug resistance mediated by QS. Over several decades, autoinducer receptors, signaling pathways, and the regulatory networks that control gene expression have corroborated QS signaling molecules. Multiple QS systems and chemical structural diversity signaling molecules have been sporadically reported, but there is no comprehensive review of these findings. This review systematically and comprehensively summarizes the paper, addressing bacterial QS-based cell-cell communication and the potential mechanisms of QS systems in bacterial drug resistance. Furthermore, a status quo update has been established for novel QS systems in the realms of pathogenicity, poly-microbial interactions, and/or antimicrobial resistance patterns. Nevertheless, the applications of QS systems would invoke newer incorporations for futuristic research values. Thus, the complexity and evolutionary insights of QS systems, quorum sensing signaling molecules (QSSMs), and regulatory mechanisms need a "cloud" based repurposing for the design of novel agents in antimicrobial resistance (AMR) and communication.
Reference Key
openalex_W7160864476 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kai-Zhong Xu, Annadurai Vinothkanna, DanDan Wang, Hongyan Jiang, Zhenbo Xu, Ai‐Qun Jia
Journal FEMS microbiology reviews
Year 2026
DOI
10.1093/femsre/fuag020
URL
https://doi.org/10.1093/femsre/fuag020
Keywords Keywords not found

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