Fear Memory-Triggered Sleep Disruption: Insights from Ventral Hippocampus-Basolateral Amygdala Manipulation
Clicks: 1
ID: 313807
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #104 of 189 articles by views in Sleep & breathing = Schlaf & Atmung
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 189 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
STUDY OBJECTIVES: A daytime fearful experience may cause sleep disturbances in the following nights, but the underlying neural circuits remain unclear. Here, we investigated how fear memory influences sleep and examined the contribution of the ventral CA1-basolateral amygdala (vCA1-BLA) pathway to fear-associated alterations in sleep. METHODS: All experiments were performed on adult male mice. To probe the effect of fear memory, we presented fear-conditioned auditory stimuli during sleep and quantified sleep-to-wake transitions, with particular attention to responses within the fear-associated context. We used calcium imaging, optogenetics, local field potential, chemogenetics, and activity-dependent genetic labeling tools (ADGLT) to assess the contribution of the vCA1-BLA pathway to sleep changes during re-exposure to fear-associated cues. RESULTS: The vCA1-BLA pathway showed stronger neuronal activity when the asleep mice were exposed to fear-conditioned auditory stimuli within the fear-associated context. Inhibiting this pathway reduced the increased transitions from sleep to wakefulness in response to re-exposure to combined contextual-auditory fear cues. Functional connectivity analysis between the vCA1 and BLA demonstrated enhanced information flow from vCA1 to BLA during tone-triggered sleep-wake transitions. Using ADGLT to re-stimulate the vCA1➔BLA neurons previously activated during fear conditioning increased stimulation-triggered sleep-to-wake transitions during sleep and elicited freezing responses during wakefulness. CONCLUSION: Enhanced activity within the vCA1-BLA circuit is associated with increased sleep-to-wake transitions when animals are exposed to combined fear-conditioned environmental and auditory conditions. These findings provide evidence that fear-associated neural ensembles can be re-engaged during sleep and may interfere with sleep continuity, highlighting a potential neural mechanism underlying fear-related sleep disturbances.
| Reference Key |
openalex_W7161018210
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Ting-Yen Lee, Min-Cheng Hsieh, Ching-Yuan Chang, Tsai-Chun Liao, Wan‐Ting Liao, Fang‐Chia Chang, Yi‐Tse Hsiao |
| Journal | Sleep & breathing = Schlaf & Atmung |
| Year | 2026 |
| DOI |
10.1093/sleep/zsag131
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.