ssDNA dynamics during mammalian meiotic recombination

Clicks: 4
ID: 313719
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #128 of 134 articles by views in biology of reproduction

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 134 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Programmed DNA double-strand breaks (DSBs) are a hallmark of meiosis, which have to be precisely repaired through meiotic recombination for ensuring genome stability and ultimately generating haploid gametes. Single-stranded DNA (ssDNA) is a central intermediate during DNA repair, primarily generated by nucleolytic resection of DSB ends and by strand displacement during homology search and strand invasion. In mammalian meiosis, resected 3' ssDNA overhangs are rapidly coated by replication protein A (RPA), which stabilizes ssDNA and prevents secondary structure formation. Subsequently, with the assistance of BRCA2 and other accessory factors, the recombinases RAD51 and DMC1 are loaded onto DSB sites to form nucleoprotein filaments. Furthermore, a meiosis-specific ssDNA-binding complex, the MEIOB/SPATA22 heterodimer, regulates recombination intermediate stability and processing. In addition, ssDNA can hybridize with RNA to form DNA-RNA hybrids, representing another way for ssDNA utilization. In this review, we summarize current knowledge of ssDNA generation, utilization, and turnover during mammalian meiotic recombination and highlight unresolved questions for further investigation.
Reference Key
openalex_W7161157796 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ruolin Cheng, Haoyang Jiang, Weicong Qin, L L Zhang, Yu Gao, Xuan Lu, Xuechun Wang, L L Zhang, Cunxian Fan, Hui Nie, Yue Wang, Xiao Yang, Shunxin Wang, L L Zhang, Binyuan Zhai
Journal biology of reproduction
Year 2026
DOI
10.1093/biolre/ioag102
URL
https://doi.org/10.1093/biolre/ioag102
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.