Multi-Center Real-World Implementation Outcomes of Lenacapavir for HIV Pre-Exposure Prophylaxis

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ID: 313432
2026
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Ranked #569 of 635 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
Lenacapavir PrEP implementation across 17 U.S. sites (n=501) was characterized by delays in initiation driven by payer processes. Early non-persistence was uncommon (3.6%) but exceeded clinical trial discontinuation rates and was strongly associated with abdominal injections and injection-site reactions requiring clinical contact, underscoring modifiable clinical and structural barriers to early persistence.
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Authors Aniruddha Hazra, Philip A. Chan, Meredith Clement, Christopher Kaperak, Hussein Safa, Joshua P Havens, Sandra A Springer, Jill Blumenthal, Matthew Spinelli, Susanne Doblecki-Lewis, Ami Multani, June Gipson, Joesph Cherabie, Rona Vail, Stephen Sukumaran, Chase A Cannon, R. Lillis, Isolde Butler, Christian Turner, Ellen Taraschi, Gilianne Narcisse-Cempini, Leah Kunzmann, Romini Smith, Drew Halbur, Rupa Patel
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Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag316
URL
https://doi.org/10.1093/cid/ciag316
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