Health-related quality of life in well-treated people with HIV and comparators over an 8-year period: a longitudinal analysis from the prospective AGEhIV cohort study

Kevin Moody; Manon C. Vanbellinghen; Pythia T. Nieuwkerk; Anders Boyd; Maarten F Schim van der Loeff; Suzanne E. Geerlings; P Reiss; Marc van der Valk; AGEhIV study group; F W N M Wit; M van der Valk; A Boyd; M L Verburgh; I A J van der Wulp; M C Vanbellinghen; C J van Eeden; M F Schim van der Loeff; J C D Koole; L del Grande; I Agard; S Zaheri; M M J Hillebregt; Y M C Ruijs; D P Benschop; A el Berkaoui; A Boyd; F W N M Wit; N A Kootstra; A M Harskamp-Holwerda; I Maurer; M M Mangas Ruiz; B D N Boeser-Nunnink; O S Starozhitskaya; L van der Hoek; M Bakker; M J van Gils; L Dol; G Rongen; S E Geerlings; A Goorhuis; J W R Hovius; F J B Nellen; J M Prins; T van der Poll; M van der Valk; W J Wiersinga; M van Vugt; G de Bree; B A Lemkes; V Spoorenberg; F W N M Wit; J van Eden; F J J Pijnappel; A Weijsenfeld; S Smalhout; I J Hylkema - van den Bout; C Bruins; M E Spelbrink; P G Postema; P H L T Bisschop; E Dekker; N van der Velde; R Franssen; J M R Willemsen; L Vogt; P Portegies; G J Geurtsen; I Visser; A Schadé; P T Nieuwkerk; R P van Steenwijk; R E Jonkers; C B L M Majoie; M W A Caan; B J H van den Born; E S G Stroes; S van Oorspronk

doi:10.1093/cid/ciag281

Health-related quality of life in well-treated people with HIV and comparators over an 8-year period: a longitudinal analysis from the prospective AGEhIV cohort study

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2026

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Ranked #413 of 531 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract

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BACKGROUND: People with HIV experience more comorbidities, which can reduce health-related quality of life (HRQoL). We compared HRQoL and depressive symptoms over 8 years in people with HIV and HIV-negative comparators in the AGEhIV study. METHODS: We assessed HRQoL biennially from 2010-2020 using SF-36 Physical (PCS) and Mental (MCS) Component Scores and measured depressive symptoms with the Center for Epidemiologic Studies Depression Scale (CES-D). Participants with ≥1 SF-36 were included; people with HIV not on ART or with HIV-1 RNA >200 copies/mL at inclusion were excluded. Mean PCS and MCS were compared between groups using mixed-effects linear regression adjusted for sociodemographics, lifestyle, and comorbidity count, with an HIV status × visit interaction. Clinically relevant depressive symptoms (CES-D ≥16) were analyzed using mixed-effects logistic regression. RESULTS: We included 522 people with HIV and 532 comparators, predominantly Dutch MSM, with median ages of 52.9 and 52.1 years, respectively. Over a median 8.0-year follow-up, mean PCS and MCS scores were lower in people with HIV by -1.69 (95% CI -2.28 to -1.10) and -1.25 (95% CI -1.97 to -0.53). Clinically relevant depressive symptoms were more frequent in people with HIV (aOR 2.74; 95% CI 1.40-5.37). Changes in PCS, MCS, and CES-D over time did not differ between groups. CONCLUSIONS: Well-treated, middle-aged people with HIV may retain HRQoL comparable to individuals without HIV, with differences that, although statistically significant, might be of unclear clinical relevance due to small effect sizes. Changes in HRQoL and depressive symptoms over time do not differ between groups.

Reference Key	openalex_W7161176913 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors	Kevin Moody, Manon C. Vanbellinghen, Pythia T. Nieuwkerk, Anders Boyd, Maarten F Schim van der Loeff, Suzanne E. Geerlings, P Reiss, Marc van der Valk, AGEhIV study group, F W N M Wit, M van der Valk, A Boyd, M L Verburgh, I A J van der Wulp, M C Vanbellinghen, C J van Eeden, M F Schim van der Loeff, J C D Koole, L del Grande, I Agard, S Zaheri, M M J Hillebregt, Y M C Ruijs, D P Benschop, A el Berkaoui, A Boyd, F W N M Wit, N A Kootstra, A M Harskamp-Holwerda, I Maurer, M M Mangas Ruiz, B D N Boeser-Nunnink, O S Starozhitskaya, L van der Hoek, M Bakker, M J van Gils, L Dol, G Rongen, S E Geerlings, A Goorhuis, J W R Hovius, F J B Nellen, J M Prins, T van der Poll, M van der Valk, W J Wiersinga, M van Vugt, G de Bree, B A Lemkes, V Spoorenberg, F W N M Wit, J van Eden, F J J Pijnappel, A Weijsenfeld, S Smalhout, I J Hylkema - van den Bout, C Bruins, M E Spelbrink, P G Postema, P H L T Bisschop, E Dekker, N van der Velde, R Franssen, J M R Willemsen, L Vogt, P Portegies, G J Geurtsen, I Visser, A Schadé, P T Nieuwkerk, R P van Steenwijk, R E Jonkers, C B L M Majoie, M W A Caan, B J H van den Born, E S G Stroes, S van Oorspronk
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year	2026
DOI	10.1093/cid/ciag281 Searching for DOI...
URL	https://doi.org/10.1093/cid/ciag281 https://doi.org/10.1093/cid/ciag281
Keywords	Keywords not found

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