NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary

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ID: 313373
2026
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Abstract
Glucocorticoids are an important signal for the differentiation of many types of cells. Consistent with this, several studies have demonstrated that glucocorticoids promote the somatotrope differentiation program and functionality. Interestingly, we previously found that loss of the forkhead factor, FOXO1, results in delayed emergence of somatotropes and prevents glucocorticoid-induced premature differentiation of somatotropes. In the current study, we find that pituitary-specific deletion of Nr3c1, the gene encoding the glucocorticoid receptor, impairs somatotrope differentiation and increases lactotrope numbers embryonically and at five days after birth. The number of somatotropes remains reduced at seven weeks of age in females and males, but lactotrope cell numbers are only increased in females at this age. FOXO1 is nearly undetectable in pituitary glands from mouse embryos lacking NR3C1 and continues to be reduced in adults. These findings suggest that glucocorticoids are an important signal for determining the balance between somatotropes and lactotropes and that FOXO1 may mediate NR3C1 induction of somatotrope differentiation.
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Authors Pratyusa Das, Ridwanullah A Abubakar, Nooshin Mojahed, Dania Abou-Jabal, Prisha Kittu, Michelle L. Brinkmeier, Jessica Olsen, Dale Ann Sunny, Sally A. Camper, Robin Lovell-Badge, Karine Rizzoti, Buffy S. Ellsworth
Journal american journal of physiology endocrinology and metabolism
Year 2026
DOI
10.1210/endocr/bqag060
URL
https://doi.org/10.1210/endocr/bqag060
Keywords Keywords not found

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