Roquefortine C Isolated from a Quail Feces-Derived Fungus Exhibits Aryl Hydrocarbon Receptor Antagonistic and Broad-Spectrum Antiviral Activities
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ID: 313365
2026
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Abstract
Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, regulates the metabolism of exogenous compounds. Pharmacological inhibition of AhR reduces lipid droplet (LD) accumulation and suppresses hepatitis C virus (HCV) proliferation. Recent evidence implicates AhR in the propagation of viruses such as herpes simplex virus type 1 (HSV-1), making it a host factor regulating the proliferation of diverse viruses and an attractive target for broad-spectrum antivirals. To identify AhR ligands with antiviral activity, we screened secondary metabolites derived from fungi isolated from various animals. We identified roquefortine C, an indole alkaloid obtained from quail-derived fungi, as an AhR antagonist. Roquefortine C suppressed LD formation and HCV production in human hepatoma cells. Additionally, it showed anti-HSV-1 and anti-pseudorabies virus (PRV) activities. Notably, our study demonstrated the relationship between AhR and PRV for the first time. AhR ligands could represent potential lead compounds with broad-spectrum antiviral properties.
| Reference Key |
openalex_W7161233621
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| Authors | Karin Maruyama, Kou Nakamura, Mitsuki Yasukochi, Hirofumi Ohashi, Shogo Nakajima, Shiki Saitoh, Nozomi Mosu, Namiho Suzuki, Chihiro Kase, Naoyuki Aihara, Hironobu Murakami, M. Okada, K. Fujino, Koichi Watashi, Shinji Kamisuki |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag070
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| URL | |
| Keywords | Keywords not found |
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