catGRANULE 2.0: accurate predictions of liquid-liquid phase separating proteins at single amino acid resolution
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ID: 311650
2025
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Abstract
Liquid-liquid phase separation (LLPS) enables the formation of membraneless organelles, essential for cellular organization and implicated in diseases. We introduce catGRANULE 2.0 ROBOT, an algorithm integrating physicochemical properties and AlphaFold-derived structural features to predict LLPS at single-amino-acid resolution. The method achieves high performance and reliably evaluates mutation effects on LLPS propensity, providing detailed predictions of how specific mutations enhance or inhibit phase separation. Supported by experimental validations, including microscopy data, it predicts LLPS across diverse organisms and cellular compartments, offering valuable insights into LLPS mechanisms and mutational impacts. The tool is freely available at https://tools.tartaglialab.com/catgranule2 and https://doi.org/10.5281/zenodo.14205831.
| Reference Key |
michele2025catgranuleaccuratepr
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| Authors | Michele Monti; Jonathan Fiorentino; Dimitrios Miltiadis-Vrachnos; Giorgio Bini; Tiziana Cotrufo; Natalia Sanchez de Groot; Alexandros Armaos; G. Tartaglia |
| Journal | Genome biology |
| Year | 2025 |
| DOI |
10.1186/s13059-025-03497-7
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| URL | |
| Keywords | Keywords not found |
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