Marchiafava-Bignami disease with rare Etiology: A Case Report
Clicks: 1
ID: 311259
2025
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #21 of 34 articles by views in Journal of Clinical Advances and Research Reviews
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Marchiafava-Bignami disease is a rare disorder of demyelination or necrosis of the corpus callosum and adjacent subcortical white matter that occurs predominantly in malnourished alcoholics[1]. The course of the disease may be acute, subacute, or chronic and is marked by dementia, spasticity, dysarthria, and inability to walk. Patients may lapse into coma and die, survive for many years in a demented condition, or occasionally recover[2]. Lesions appear as hypodense areas in portions of the corpus callosum on computed tomography (CT) and as discrete or confluent areas of decreased T1 signal and increased T2 signal on magnetic resonance imaging (MRI)[3]. Alcohol abusers without liver disease, amnesia, or cognitive dysfunction show thinning of the corpus callosum at autopsy[4] and on MRI[5,6], suggesting that alcohol or malnutrition damages the corpus callosum commonly in the absence of the necrotic lesions of Marchiafava-Bignami disease. These findings raise the possibility that aggressive nutritional supplementation along with a reduction in drinking can prevent the development of Marchiafava-Bignami disease in alcohol abusers. Here, we present a case report of MBD diagnosed in a 60 year-old male who presented with gait instability and slurred speech, in an effort to highlight the importance of obtaining MRI in patients presenting with behavioural disturbance and neurological findings, as well as discuss the relationship between thiamine supplementation and demyelinating diseases in the central nervous system.
| Reference Key |
imported_1770374169_6985c419e8523
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yash Rajan, Darsh Vaghani, Kathrotiya Vishal, Sunil Kumar |
| Journal | Journal of Clinical Advances and Research Reviews |
| Year | 2025 |
| DOI |
10.62896/jcarr.v2.i2.02
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.