Abstract IA-19: Deconstructing metastasis

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ID: 310841
2009
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Abstract
Abstract Metastasis is a multi-stage process that selects for circulating cancer cells that can infiltrate, survive in, and colonize distant organs. The cellular origin, oncogenic alterations, tissue affinities, and circulation patterns of tumors markedly influence the sites and temporal course of metastasis. Cancer cell dissemination may be followed by a protracted period of latency before relapse in one or more organs, as in breast cancer, or by a swift colonization of multiple organs, as in lung adenocarcinoma. We have sought to incorporate this varied biology into experimental models to deconstruct metastasis. Searching for mechanisms that prime breast cancer cells for infiltration of different organs, we found few requirements for cancer cell extravasation through fenestrated bone marrow capillaries, certain key requirements (EGFR ligands, COX2, TGFβ-induced angiopoietin-like 4) for infiltration through the non-fenestrated walls of lung and brain capillaries, and additional mediators (sialyl transferase ST6GalNac5) for infiltration though brain capillaries with blood-brain barrier. Searching for mechanisms that allow infiltrated breast cancer cells to survive as latent disease, we found that a hyperactive SRC pathway supports the responsiveness of breast cancer cells to certain survival factors in the marrow microenvironment. Searching for mechanisms that in contrast underlie the rapid metastasis of lung adenocarcinomas to brain and bone, we uncovered an involvement of WNT/TCF signaling through HOXH9 and LEF1. These striking disparities in the natural progression of different cancers bring into focus important questions about the evolution of metastatic traits, the molecular mediators involved, and the treatment opportunities for the prevention of metastasis. Citation Information: Cancer Res 2009;69(23 Suppl):IA-19.
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joan2009abstractiadeconstruc Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Joan Massagué
Journal Cancer research
Year 2009
DOI
10.1158/0008-5472.fbcr09-ia-19
URL
https://aacrjournals.org/cancerres/article/69/23_Supplement/IA-19/550158/Abstract-IA-19-Deconstructing-metastasis
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