Impact of constant low-gas pressure on cardiopulmonary parameters and surgical outcomes in extraperitoneal full nerve-sparing robot-assisted radical prostatectomy

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Abstract
Abstract: Traditionally, in EP-RARP, a pneumo-Retzius is obtained by using a CO2 insufflation pressure of 12-15 mmHg. However, EP surgery is associated with an increase in CO2 absorption and consequent hypercapnia and acidosis. The aim of this study was to compare the effect of low CO2 pressure (8 mmHg) to a conventional gas pressure in EP-RARP. We enrolled patients with low-risk prostate cancer who underwent full nerve-sparing RARP using our PERUSIA technique. Exclusion criteria were chronic lung diseases, positive bioptic core in anterior zone, shift to transperitoneal approach. Cardiopulmonary parameters were measured at the induction of anesthesia (T0), at 5 (T1), 60 (T2) minutes after starting CO₂ insufflation, and immediately after DVC dissection before urethro-vesical anastomosis (T3). Data from 120 consecutive patients were retrospectively analyzed from a prospectively maintained database. Patients were divided into two groups based on the CO₂ insufflation pressure (8 vs 12 mmHg). No significant differences were detected in mean operative time, in time required for trocar positioning, in mean estimated blood loss and in complications between the two group. The only significant difference was in PaCO2, higher at T3 in Group 2 (p 0.005), with a consequent reduction in arterial pH, however not significant (p=0.44). EP-RARP can be safely performed using low CO2 insufflation pressure. From anesthesiologic point of view, this advantage could extend eligibility criteria to EP-RARP to patients with chronic pulmonary diseases.
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Authors Mearini, Ettore
Journal Frontiers in surgery
Year Year not found
DOI
10.3389/fsurg.2025.1702676
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