Diagnosing and Treating Sinonasal Glomangiopericytoma: A Case Study

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Abstract
Background: sinonasal glomangiopericytoma(SNGP) is a rare neoplasm with distinct clinical and pathological characteristics, typically presenting in the sinonasal region and accounting for less than 0.5% of all sinonasal tumors. This case report describes a 74-year-old male with SNGP and reviews the relevant literature to enhance understanding and management of this rare entity. Case Presentation: The patient presented with a one-year history of intermittent left-sided epistaxis and decreased left nasal olfaction. Imaging studies revealed a mass in the left nasal cavity, and endoscopic sinus surgery was performed, with pathology confirming SNGP. Immunohistochemistry results were consistent with SNGP, showing positive staining for SMA, F8, CD99, cyclin D1, β-catenin and negative for Bcl-2, Ki67 and CD117. The treatment involved a comprehensive surgical approach, where the tumor was completely resected. Postoperatively, the patient did not receive any adjuvant therapy, and regular follow-ups were conducted to monitor for recurrence or metastasis. Conclusion: SNGP, when completely resected, has a favorable prognosis. This case highlights the critical role of histopathological examination and immunohistochemistry in diagnosing SNGP. The patient has been followed up for over three years with no signs of tumor recurrence or distant metastasis, indicating the effectiveness of the surgical intervention and the benign nature of the tumor. The importance of long-term follow-up is emphasized to monitor for potential recurrences, given the indolent biological behavior of SNGP. This case underscores the significance of a multidisciplinary approach, including surgery and pathology, in achieving optimal outcomes for patients with SNGP.
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Authors Yin, Min
Journal Frontiers in surgery
Year Year not found
DOI
10.3389/fsurg.2025.1660934
URL
https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2025.1660934/full
Keywords Keywords not found

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