Late-onset anti-Yo antibody-positive paraneoplastic cerebellar degeneration: a case report

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ID: 310109
2026
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Abstract
Anti-Yo antibody-positive paraneoplastic cerebellar degeneration (PCD) is a rare immune-mediated neurological syndrome associated with malignancy, presenting significant diagnostic and therapeutic challenges. This case describes an elderly female patient who developed delayed-onset subacute cerebellar symptoms three years after ovarian cancer resection, ultimately diagnosed with anti-Yo antibody-positive PCD. Although immunotherapy was administered, the patient's ataxia exhibited only limited improvement, suggesting that PCD may progress to an irreversible pathological stage. This case challenges the conventional understanding that PCD typically precedes tumour detection, offering a new perspective on clinical diagnosis and management due to the three-year interval. This case underscores the importance of considering paraneoplastic etiology in patients with unexplained neurological deficits who have a history of tumor surgery. Maintaining awareness for long-term screening for PCD and early management of primary malignancies alongside immunological interventions is crucial for delaying disease progression.
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imported_1768922128_696f9c1059376 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhibiao, Cai
Journal Frontiers in surgery
Year 2026
DOI
10.3389/fsurg.2025.1676024
URL
https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2025.1676024/full
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