Activity of Biocidin® against microbial biofilms
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ID: 310043
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Abstract
Biofilms – microbial communities – are present throughout the environment and interact with humans as part of the resident microbiome or when causing infection and disease. Antibiotics are commonly used to treat bacterial infections, including the ones due to biofilms. However, antimicrobial tolerance and resistance are common traits of these microbial communities. Resistance to antimicrobials is now widely found and the search for alternative treatments, such as plant/herbal extracts, essential oils, and honey, is on the rise. Here, we investigated the effect of Biocidin®, a botanical supplement on biofilms of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans. A single (bolus) dose of Biocidin® resulted in a significant decrease (> 2 Log) of biofilm and planktonic populations, while a 24-hour continuous dose of 25% and 50% Biocidin® led to a typical biphasic killing curve resulting in biofilm eradication of P. aeruginosa, S. aureus, and E. coli, in the latter concentration. Exposure to sub-inhibitory concentrations of Biocidin® did not affect biofilm viability. Results from this work have implications for the use of Biocidin® as a treatment of biofilm infections and as a supplement in natural medicine.
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imported_1768918433_696f8da1dd578
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| Authors | Marques, Claudia NH |
| Journal | Frontiers in surgery |
| Year | Year not found |
| DOI |
10.3389/frabi.2025.1692653
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| URL | |
| Keywords | Keywords not found |
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