The Taconic Foredeep as sediment sink and sediment exporter; implications for the origin of the White Quartzarenite blanket (Upper Ordovician-Lower Silurian) of the Central and Southern Appalachians

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ID: 308052
1995
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Abstract
Rationale: There is no information on the characteristics of subjects sampled from the general population with mild to moderate COPD who are susceptible to exacerbation-like respiratory events. Objective: Assess in a population-based sample, if there are differences between the characteristics of subjects with COPD who report exacerbation-like events and those who do not. Methods: Canadian Cohort Obstructive Lung Disease (CanCOLD) is a longitudinal, multi-center study, 1400 subjects, ≥40 years old, identified by random digit dialling from the general population. Subjects are sex- and age-matched, and grouped:1) COPD moderate+ (GOLD≥2); 2) COPD mild (GOLD1); 3) at risk (ever smoker); 4) healthy (never smoker, no obstruction). An exacerbation questionnaire is administered at baseline and every 3 months to detect changes in respiratory symptoms, medication, work and health service use. Results: In a preliminary analysis of 372 subjects with COPD, 73 reported having an exacerbation-like event during a 6-month follow-up, 299 did not. Subjects who reported at least 1 event had greater BODE scores, a 2-fold increase in respiratory medication, and decreased lung function and health status. Smoking, MRC dyspnea score and co-morbidities were not associated with exacerbation events. Frequency of exacerbations increased with disease severity. Conclusions: From a population-sampling based cohort that mirrors the population of COPD patients at large,exacerbation-like respiratory events are associated with worsening disease manifestation in subjects with mild or moderate COPD. Longitudinal evaluation will allow for phenotype analysis.
Reference Key
openalex_W2327687657 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J. Dorsch, Steven G. Driese
Journal american journal of science
Year 1995
DOI
10.2475/ajs.295.2.201
URL
https://ajsonline.org/article/60674.pdf
Keywords Keywords not found

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