Fauna of the Great Smoky Mountains

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Abstract
The stability of carzelesin in a polyethylene glycol 400 (PEG 400)/absolute ethanol/polysorbate 80 (Tween 80) (6:3:1, v/v/v) formulation (PET formulation) was investigated as a function of the inter-batch variability of the three excipients. Twenty different PET formulations were tested and the stability of carzelesin in the PET formulation was found to be influenced by the type of PEG 400 used. Subsequent investigations showed that the pH of PEG 400, and consequently the pH of the PET formulation, was responsible for the variable stability characteristics of carzelesin in the PET formulation. The higher the pH of the PET formulation, the higher the rate of degradation of carzelesin in PET. The major degradation products were found to be U-76,073 and U-76,074.
Reference Key
openalex_W2331519226 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors C. H. Merriam
Journal american journal of science
Year 1888
DOI
10.2475/ajs.s3-36.216.458
URL
https://ajsonline.org/article/62690.pdf
Keywords Keywords not found

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