Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

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ID: 307665
2011
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Abstract
Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a worldwide health problem. The continuous dissemination of ‘multidrug-resistant’ (MDR) bacteria drastically reduces the efficacy of our antibiotic ‘arsenal’ and consequently increases the frequency of therapeutic failure. In MDR bacteria, the overexpression of efflux pumps that expel structurally unrelated drugs contributes to the reduced susceptibility by decreasing the intracellular concentration of antibiotics. During the last decade, several clinical data have indicated an increasing involvement of efflux pumps in the emergence and dissemination of resistant Gram-negative bacteria. It is necessary to clearly define the molecular, functional and genetic bases of the efflux pump in order to understand the translocation of antibiotic molecules through the efflux transporter. The recent investigation on the efflux pump AcrB at its structural and physiological levels, including the identification of drug affinity sites and kinetic parameters for various antibiotics, may pave the way towards the rational development of an improved new generation of antibacterial agents as well as efflux inhibitors in order to efficiently combat efflux-based resistance mechanisms.
Reference Key
openalex_W1785018154 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hiroshi Nikaido, Jean‐Marie Pagès
Journal FEMS microbiology reviews
Year 2011
DOI
10.1111/j.1574-6976.2011.00290.x
URL
https://academic.oup.com/femsre/article-pdf/36/2/340/18129109/36-2-340.pdf
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