Factors Affecting Adherence to Antiretroviral Therapy

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ID: 307619
2000
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Ranked #475 of 531 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
In both clinical trials and clinical practice, nonadherence to medications is widespread among patients with chronic diseases. The shift to combination therapies for treating human immunodeficiency virus (HIV)-infected individuals has increased adherence challenges for both patients and health-care providers. Estimates of average rates of nonadherence to antiretroviral therapy range from 50% to 70%. Adherence rates of <80% are associated with detectable viremia in a majority of patients. The principal factors associated with nonadherence appear to be patient-related, including substance and alcohol abuse. However, other factors may also contribute, such as inconvenient dosing frequency, dietary restrictions, pill burden, and side effects; patient-health-care provider relationships; and the system of care. We discuss the major reasons reported by HIV-infected individuals for not taking their medications. Improving adherence probably requires clarifying the treatment regimen and tailoring it to patient lifestyles.
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Authors Margaret A. Chesney
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2000
DOI
10.1086/313849
URL
https://academic.oup.com/cid/article-pdf/30/Supplement_2/S171/20903717/30-Supplement_2-S171.pdf
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