Gastrointestinal Microflora Studies in Late‐Onset Autism

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ID: 307572
2002
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Ranked #276 of 531 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridium not found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found. In gastric and duodenal specimens, the most striking finding was total absence of non—spore-forming anaerobes and microaerophilic bacteria from control children and significant numbers of such bacteria from children with autism. These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder.
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openalex_W2099856240 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sydney M. Finegold, Denise Molitoris, Yuli Song, Chengxu Liu, Marja–Liisa Väisänen, Ellen R Bolte, M. McTeague, Richard H. Sandler, Hannah M. Wexler, Elizabeth M. Marlowe, Matthew D. Collins, Paul A. Lawson, Paula Summanen, Mehmet Baysallar, Thomas J. Tomzynski, Erik K. Read, Eric A. Johnson, Rial D. Rolfe, Palwasha Nasir, Haroun N. Shah, David A. Haake, Patricia Manning, Ajay Kaul
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2002
DOI
10.1086/341914
URL
https://academic.oup.com/cid/article-pdf/35/Supplement_1/S6/20904898/35-Supplement_1-S6.pdf
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