The gut microbiota regulates bone mass in mice

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ID: 307183
2012
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Ranked #6 of 143 articles by views in journal of bone and mineral research : the official journal of the american society for bone and mineral research

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Abstract
The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ-free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventionally raised (CONV-R) mice. Colonization of GF mice with a normal gut microbiota normalizes bone mass. Furthermore, GF mice have decreased frequency of CD4+ T cells and CD11b+/GR 1 osteoclast precursor cells in bone marrow, which could be normalized by colonization. GF mice exhibited reduced expression of inflammatory cytokines in bone and bone marrow compared with CONV-R mice. In summary, the gut microbiota regulates bone mass in mice, and we provide evidence for a mechanism involving altered immune status in bone and thereby affected osteoclast-mediated bone resorption. Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis. © 2012 American Society for Bone and Mineral Research.
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Authors Klara Sjögren, Cecilia Engdahl, Petra Henning, Ulf H. Lerner, Valentina Tremaroli, Marie K. Lagerquist, Fredrik Bäckhed, Claes Ohlsson
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Journal journal of bone and mineral research : the official journal of the american society for bone and mineral research
Year 2012
DOI
10.1002/jbmr.1588
URL
https://doi.org/10.1002/jbmr.1588
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