Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

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ID: 306759
1997
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Ranked #267 of 301 articles by views in american journal of physiology endocrinology and metabolism

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Abstract
Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic nuclei suggests that multiple neuronal subtypes are targets for leptin's action. Products of the proopiomelanocortin (POMC) gene are known to affect feeding behavior, and POMC neurons share a similar distribution with leptin receptor mRNA in the arcuate nucleus. We used double label in situ hybridization and computerized image analysis to test the hypothesis that POMC neurons coexpress the leptin receptor. Quantitative analysis confirmed that POMC neurons in the hypothalamus express leptin receptor mRNA. Based on this observation, we infer that POMC neurons and the products of the POMC gene may be part of the signaling pathway mediating leptin's action on feeding and perhaps other physiological functions.
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openalex_W2129221666 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Clement C. Cheung, Donald K. Clifton, Robert A. Steiner
Journal american journal of physiology endocrinology and metabolism
Year 1997
DOI
10.1210/endo.138.10.5570
URL
https://academic.oup.com/endo/article-pdf/138/10/4489/10359181/endo4489.pdf
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