The Pharmacokinetic and Pharmacodynamic Properties of Vancomycin

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ID: 306032
2005
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Ranked #392 of 532 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
Vancomycin is one of only a few antibiotics available to treat patients infected with methicillin-resistant Staphylococcus aureus and methicillin-resistant, coagulase-negative Staphylococcus species. Therefore, understanding the clinical implications of the pharmacokinetic and pharmacodynamic properties of vancomycin is a necessity for clinicians. Vancomycin is a concentration-independent antibiotic (also referred to as a "time-dependent" antibiotic), and there are factors that affect its clinical activity, including variable tissue distribution, inoculum size, and emerging resistance. This article reviews the pharmacokinetic and pharmacodynamic data related to vancomycin and discusses such clinical issues as toxicities and serum concentration monitoring.
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Authors Michael J. Rybak
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2005
DOI
10.1086/491712
URL
https://academic.oup.com/cid/article-pdf/42/Supplement_1/S35/20907110/42-Supplement_1-S35.pdf
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