Complexity of the Alternative Splicing Landscape in Plants

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ID: 305880
2013
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Abstract
Abstract Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows organisms to increase their coding potential and regulate gene expression through multiple mechanisms. Recent transcriptome-wide analysis of AS using RNA sequencing has revealed that AS is highly pervasive in plants. Pre-mRNAs from over 60% of intron-containing genes undergo AS to produce a vast repertoire of mRNA isoforms. The functions of most splice variants are unknown. However, emerging evidence indicates that splice variants increase the functional diversity of proteins. Furthermore, AS is coupled to transcript stability and translation through nonsense-mediated decay and microRNA-mediated gene regulation. Widespread changes in AS in response to developmental cues and stresses suggest a role for regulated splicing in plant development and stress responses. Here, we review recent progress in uncovering the extent and complexity of the AS landscape in plants, its regulation, and the roles of AS in gene regulation. The prevalence of AS in plants has raised many new questions that require additional studies. New tools based on recent technological advances are allowing genome-wide analysis of RNA elements in transcripts and of chromatin modifications that regulate AS. Application of these tools in plants will provide significant new insights into AS regulation and crosstalk between AS and other layers of gene regulation.
Reference Key
openalex_W2109322710 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Anireddy S. N. Reddy, Yamile Márquez, Maria Kalyna, Andrea Barta
Journal The Plant cell
Year 2013
DOI
10.1105/tpc.113.117523
URL
https://doi.org/10.1105/tpc.113.117523
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