Study of Telomere Length Reveals Rapid Aging of Human Marrow Stromal Cells following In Vitro Expansion

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ID: 305597
2004
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Abstract
Human marrow stromal cells (MSCs) can be isolated from bone marrow and differentiate into multiple tissues in vitro and in vivo. These properties make them promising tools in cell and gene therapy. The lack of a specific MSC marker and the low frequency of MSCs in bone marrow necessitate their isolation by in vitro expansion prior to clinical use. This may severely reduce MSC proliferative capacity to the point that the residual proliferative potential is insufficient to maintain long‐term tissue regeneration upon reinfusion. In this study we determined the effect of in vitro expansion on the replicative capacity of MSCs by correlating their rate of telomere loss during in vitro expansion with their behavior in vivo. We report that even protocols that involve minimal expansion induce a rapid aging of MSCs, with losses equivalent to about half their total replicative lifespan.
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openalex_W1998461585 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors M. Baxter, Robert Wynn, Simon N. Jowitt, J. E. Wraith, Leslie J. Fairbairn, Ilaria Bellantuono
Journal stem cells international
Year 2004
DOI
10.1634/stemcells.22-5-675
URL
https://academic.oup.com/stmcls/article-pdf/22/5/675/40638981/stmcls_22_5_675.pdf
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