Studies in the Cyperaceae; Carices aeorastachyae, Crinite nob., Apertae nob., and Magnificae nob.

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ID: 305338
1921
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Abstract
1) The antagonism of d-tubocurarine, c-curarine-I, c-toxiferine-II, and β-erythroidine to the acetyicholine contracture of the frog9s rectus abdominis was studied. 2) The antagonism can be expressed by means of an activity constant derived from the law of mass action. For the three quaternary alkaloids this activity constant (recorded in fig. 4) is independent of the concentration of the curare alkaloid used; for the tertiary amine, β-erythroidine, the activity constant increases when the concentration is increased. 3) The rectus abdominis muscle of the frog reaches an equilibrium faster with acetylcholine than with d-tubocurarine. 4) Since the dose-response curve for acetylcholine is shifted only along the dose scale and the same maximal response is obtained even though the curare alkaloid is present, the antagonism between acetylcholine and the curare alkaloids used is competitive. 5) Variation of temperature (5°-35°C.) and of potassium ion concentration (1-8 mM/L.) does not significantly change the average value of the activity constant of d-tubocurarine.
Reference Key
openalex_W2330720506 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Theo. Holm
Journal american journal of science
Year 1921
DOI
10.2475/ajs.s5-2.11.285
URL
https://doi.org/10.2475/ajs.s5-2.11.285
Keywords Keywords not found

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