Universal rules and idiosyncratic features in tRNA identity

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ID: 305212
1998
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Abstract
Correct expression of the genetic code at translation is directly correlated with tRNA identity. This survey describes the molecular signals in tRNAs that trigger specific aminoacylations. For most tRNAs, determinants are located at the two distal extremities: the anticodon loop and the amino acid accepting stem. In a few tRNAs, however, major identity signals are found in the core of the molecule. Identity elements have different strengths, often depend more on kcat effects than on Km effects and exhibit additive, cooperative or anticooperative interplay. Most determinants are in direct contact with cognate synthetases, and chemical groups on bases or ribose moieties that make functional interactions have been identified in several systems. Major determinants are conserved in evolution; however, the mechanisms by which they are expressed are species dependent. Recent studies show that alternate identity sets can be recognized by a single synthetase, and emphasize the importance of tRNA architecture and anti-determinants preventing false recognition. Identity rules apply to tRNA-like molecules and to minimalist tRNAs. Knowledge of these rules allows the manipulation of identity elements and engineering of tRNAs with switched, altered or multiple specificities.
Reference Key
openalex_W2057892106 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors R. Giegé, Marie Sissler, Catherine Florentz
Journal Nucleic Acids Research
Year 1998
DOI
10.1093/nar/26.22.5017
URL
https://academic.oup.com/nar/article-pdf/26/22/5017/6396499/26-22-5017.pdf
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