Cortical lesions in multiple sclerosis

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ID: 305198
1999
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Abstract
Although previous studies have shown that the lesions of multiple sclerosis may involve the cerebral cortex, there is little published research on the prevalence and distribution of such lesions. Using neuropathological techniques and MRI, a series of studies has been undertaken in order to assess this, in particular to identify their relationship to cortical veins. A serial MRI study showed that the use of gadolinium proffered an increase in cortical lesion detection of 140% and showed that 26% of active lesions arose within or adjacent to the cortex. In a post-mortem study, MRI under-reported lesions subsequently analysed neuropathologically, particularly those arising within the cortex. In a further 12 cases examined, 478 cortical lesions were identified, of which 372 also involved the subcortical white matter. Seven different lesion types were identified; the majority arose within the territory of the principal cortical veins, whilst the remaining quarter arose within the territory of the small branch or superficial veins. Small cortical lesions are common in multiple sclerosis and are under-reported by MRI. Investigation of the cortical venous supply shows how such lesions may arise, and why the majority also involve the underlying white matter.
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openalex_W2164721910 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Desmond P. Kidd, Frederik Barkhof, R. B. McConnell, Paul R. Algra, Ingrid V. Allen, T Révész
Journal Brain research
Year 1999
DOI
10.1093/brain/122.1.17
URL
https://doi.org/10.1093/brain/122.1.17
Keywords Keywords not found

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