Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I)

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ID: 305172
1998
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Abstract
The rate-limiting enzyme in arachidonate metabolism is mediated by enzymes known as cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 , the precursor of molecules, such as prostaglandins, prostacyclin, and thromboxanes. The COX enzyme family consists of the classical COX-1 enzyme, which is constitutively expressed in many tissues, and a second enzyme, i.e., COX-2, which is induced by various stimuli, such as mitogens and cytokines, and is involved in many inflammatory reactions. Because nonsteroidal anti-inflammatory drugs inhibit both COX-1 and COX-2, these drugs also cause unwanted side effects, exemplified by gastrointestinal bleeding. Accumulating evidence indicates that nonsteroidal anti-inflammatory drugs can reduce the incidence of colorectal cancers in human and experimental animals and can reduce the polyp number and size in patients with familial adenomatous polyposis. This Part I (of a two-part review) focuses on the discovery of the COXs; their biochemical, molecular, and structural properties; and on the discovery of isozyme-specific inhibitors of COX activity. [J Natl Cancer Inst 1998;90:1529-36]
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openalex_W2117580825 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Makoto M. Taketo
Journal JNCI Journal of the National Cancer Institute
Year 1998
DOI
10.1093/jnci/90.20.1529
URL
https://academic.oup.com/jnci/article-pdf/90/20/1529/7683976/90-20-1529.pdf
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