LOMETS: A local meta-threading-server for protein structure prediction

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ID: 304718
2007
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Abstract
We developed LOMETS, a local threading meta-server, for quick and automated predictions of protein tertiary structures and spatial constraints.Nine state-of-the-art threading programs are installed and run in a local computer cluster, which ensure the quick generation of initial threading alignments compared with traditional remoteserver-based meta-servers.Consensus models are generated from the top predictions of the component-threading servers, which are at least 7% more accurate than the best individual servers based on TM-score at a t-test significance level of 0.1%.Moreover, side-chain and C-alpha (C a ) contacts of 42 and 61% accuracy respectively, as well as long-and short-range distant maps, are automatically constructed from the threading alignments.These data can be easily used as constraints to guide the ab initio procedures such as TASSER for further protein tertiary structure modeling.The LOMETS server is freely available to the academic community at http://zhang.bioinformatics.ku.edu/LOMETS.a ACC sc : Average accuracy for side-chain center of mass contact predictions.b Cov sc : Average coverage for side-chain center of mass
Reference Key
openalex_W2126677834 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sitao Wu, Yang Zhang
Journal Nucleic Acids Research
Year 2007
DOI
10.1093/nar/gkm251
URL
https://doi.org/10.1093/nar/gkm251
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