Vancomycin: A History

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ID: 304366
2005
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Ranked #461 of 531 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
Vancomycin became available for clinical use >50 years ago but was soon discarded in favor of other antibiotics that were deemed to be more efficacious and less toxic. The advent of pseudomembranous enterocolitis, coupled with the spread of methicillin-resistant Staphylococcus aureus, led to a resurgence in the use of vancomycin. Almost immediately, concerns arose with regard to its therapeutic utility. In addition, resistance to vancomycin developed, first in enterococci and later in staphylococci. Several types of resistance have now been identified, each with a unique effect on infections treated with vancomycin. Recent studies have rekindled interest in the best way to administer the antibiotic. The findings of future studies may result in a return to measuring levels of vancomycin in serum, to assure a successful therapeutic outcome.
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Authors Donald P. Levine
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2005
DOI
10.1086/491709
URL
https://academic.oup.com/cid/article-pdf/42/Supplement_1/S5/20907230/42-Supplement_1-S5.pdf
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