Radiotherapy Alone Versus Combined Chemotherapy and Radiotherapy in Nonresectable Non-Small-Cell Lung Cancer: First Analysis of a Randomized Trial in 353 Patients
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ID: 303686
1991
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Abstract
We report the results observed in a large, randomized study that compared the effects of radiotherapy alone (the standard therapy) with those of a combination of radiotherapy and chemotherapy in nonresectable squamous cell and large-cell lung carcinoma. The radiation dose was 65 Gy in each group, and chemotherapy included vindesine, cyclophosphamide, cisplatin, and lomustine. In this study, 177 patients received radiotherapy alone (group A), and 176 patients received the combined treatment (group B). The 2-year survival rate was 14% in group A and 21% in group B (P = .08). The distant metastasis rate was significantly lower in group B (P less than .001). Local control was poor in both groups (17% and 15%, respectively) and remained the major problem.
| Reference Key |
openalex_W2138310931
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| Authors | Thierry Le Chevalier, R. Arriagada, Élisabeth Quoix, P. Rufflé, María P. Martín, Michèle Tarayre, L.-T. Marie-Jose, Jean‐Yves Douillard, A. Laplanche |
| Journal | JNCI Journal of the National Cancer Institute |
| Year | 1991 |
| DOI |
10.1093/jnci/83.6.417
|
| URL | |
| Keywords | Keywords not found |
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