Risk of Infectious Complications in Patients Taking Glucocorticosteroids

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ID: 303314
1989
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Ranked #375 of 531 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
The association between corticosteroid therapy and subsequent infections was calculated by pooling data from 71 controlled clinical trials. The overall rate of infectious complications was 12.7% in the 2,111 patients randomly allocated to systemic corticosteroids and 8.0% in the 2,087 controls (relative risk [RR], 1.6; 95% confidence interval [CI], 1.3–1.9; P < .001). The risk of infection was particularly high in patients with neurologic diseases (RR, 2.8; 95% CI, 1.9–4.3; P< .001) and less pronounced in patients with intestinal (RR, 1.4; 95% CI, 1.1–1.7; P = .02), hepatic (RR, 1.4; 95% CI, 0.9–2.3; P = .25), and renal (RR>1; P = .03) diseases. The rate was not increased in patients given a daily dose of <10 mg or a cumulative dose of <700 mg of prednisone. With increasing doses the rate of occurrence of infectious complications increased in patients given corticosteroids as well as in patients given placebo, a finding suggesting that not only the corticosteroid but also the underlying disease state account for the steroid-associated infectious complications observed in clinical practice.
Reference Key
openalex_W1975347539 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Andreas E. Stuck, C. E. Minder, Felix J. Frey
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 1989
DOI
10.1093/clinids/11.6.954
URL
https://doi.org/10.1093/clinids/11.6.954
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