PoPoolation2: identifying differentiation between populations using sequencing of pooled DNA samples (Pool-Seq)

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ID: 302633
2011
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Abstract
Abstract Summary: Sequencing pooled DNA samples (Pool-Seq) is the most cost-effective approach for the genome-wide comparison of population samples. Here, we introduce PoPoolation2, the first software tool specifically designed for the comparison of populations with Pool-Seq data. PoPoolation2 implements a range of commonly used measures of differentiation (FST, Fisher's exact test and Cochran-Mantel-Haenszel test) that can be applied on different scales (windows, genes, exons, SNPs). The result may be visualized with the widely used Integrated Genomics Viewer. Availability and Implementation: PoPoolation2 is implemented in Perl and R. It is freely available on http://code.google.com/p/popoolation2/ Contact: christian.schloetterer@vetmeduni.ac.at Supplementary Information: Manual: http://code.google.com/p/popoolation2/wiki/Manual Test data and tutorial: http://code.google.com/p/popoolation2/wiki/Tutorial Validation: http://code.google.com/p/popoolation2/wiki/Validation
Reference Key
openalex_W2161950199 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Robert Kofler, Ram Vinay Pandey, Christian Schlötterer
Journal BMC Bioinformatics
Year 2011
DOI
10.1093/bioinformatics/btr589
URL
https://doi.org/10.1093/bioinformatics/btr589
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