Regulatory T cells: how do they suppress immune responses?
Клики: 55
ID: 302626
2009
Метрики качества и эффективности статьи
Общее качество
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Вовлечённость читателей
Steady Performance
16.2
/100
55 просмотры
8 читатели
Оценка качества ИИ
Не проанализировано
Readership in this journal
SteadyRanked #3 of 42 articles by views in international immunology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Аннотация
Regulatory T cells (Tregs), either natural or induced, suppress a variety of physiological and pathological immune responses. One of the key issues for understanding Treg function is to determine how they suppress other lymphocytes at the molecular level in vivo and in vitro. Here we propose that there may be a key suppressive mechanism that is shared by every forkhead box p3 (Foxp3)+ Treg in vivo and in vitro in mice and humans. When this central mechanism is abrogated, it causes a breach in self-tolerance and immune homeostasis. Other suppressive mechanisms may synergistically operate with this common mechanism depending on the environment and the type of an immune response. Further, Treg-mediated suppression is a multi-step process and impairment or augmentation of each step can alter the ultimate effectiveness of Treg-mediated suppression. These findings will help to design effective ways for controlling immune responses by targeting Treg suppressive functions.
| Ссылочный ключ |
openalex_W2105484520
Используйте этот ключ для автоцитирования в рукописи при использовании
SciMatic Manuscript Manager или Thesis Manager
|
|---|---|
| Авторы | Shimon Sakaguchi, Kajsa Wing, Y. Onishi, Paz Prieto-Martin, Tomoyuki Yamaguchi |
| Журнал | international immunology |
| Год | 2009 |
| DOI |
10.1093/intimm/dxp095
|
| URL | |
| Ключевые слова | Ключевые слова не найдены |
Цитирования
Цитирования не найдены. Чтобы добавить цитирование, свяжитесь с администратором по адресу info@scimatic.org
Комментарии
Комментариев пока нет. Будьте первым, кто прокомментирует эту статью.