Support vector machine approach for protein subcellular localization prediction

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ID: 302198
2001
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Abstract
Subcellular localization is a key functional characteristic of proteins. A fully automatic and reliable prediction system for protein subcellular localization is needed, especially for the analysis of large-scale genome sequences.In this paper, Support Vector Machine has been introduced to predict the subcellular localization of proteins from their amino acid compositions. The total prediction accuracies reach 91.4% for three subcellular locations in prokaryotic organisms and 79.4% for four locations in eukaryotic organisms. Predictions by our approach are robust to errors in the protein N-terminal sequences. This new approach provides superior prediction performance compared with existing algorithms based on amino acid composition and can be a complementary method to other existing methods based on sorting signals.A web server implementing the prediction method is available at http://www.bioinfo.tsinghua.edu.cn/SubLoc/.Supplementary material is available at http://www.bioinfo.tsinghua.edu.cn/SubLoc/.
Reference Key
openalex_W2160979370 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sujun Hua, Zhirong Sun
Journal BMC Bioinformatics
Year 2001
DOI
10.1093/bioinformatics/17.8.721
URL
Keywords Keywords not found

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