QMEAN server for protein model quality estimation

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ID: 302157
2009
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Abstract
Model quality estimation is an essential component of protein structure prediction, since ultimately the accuracy of a model determines its usefulness for specific applications. Usually, in the course of protein structure prediction a set of alternative models is produced, from which subsequently the most accurate model has to be selected. The QMEAN server provides access to two scoring functions successfully tested at the eighth round of the community-wide blind test experiment CASP. The user can choose between the composite scoring function QMEAN, which derives a quality estimate on the basis of the geometrical analysis of single models, and the clustering-based scoring function QMEANclust which calculates a global and local quality estimate based on a weighted all-against-all comparison of the models from the ensemble provided by the user. The web server performs a ranking of the input models and highlights potentially problematic regions for each model. The QMEAN server is available at http://swissmodel.expasy.org/qmean.
Reference Key
openalex_W2105638686 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pascal Benkert, Michael Künzli, Torsten Schwede
Journal Nucleic Acids Research
Year 2009
DOI
10.1093/nar/gkp322
URL
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