Long-term fracture prediction by bone mineral assessed at different skeletal sites

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ID: 301772
1993
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Ranked #63 of 120 articles by views in journal of bone and mineral research : the official journal of the american society for bone and mineral research

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Abstract
Abstract Bone mineral density (BMD) was measured at the lumbar spine and cervical and intertrochanteric regions of the proximal femur by dual-photon absorptiometry and bone mineral content was assessed at the distal and midradius by single-photon absorptiometry in an age-stratified random sample of 304 Rochester, Minnesota women aged 30–94 years. Over follow-up extending to 10 years (median 8.3 years), 93 women experienced 163 new fractures. After adjusting for age, these bone mineral measurements predicted the likelihood of any incident fracture due to moderate trauma, with relative hazards varying from 1.4 to 1.6 per SD decrease in baseline bone mineral. A 1 SD decrease in lumbar spine BMD increased the risk of a new vertebral fracture comparably to a 17 year increase in age; a 1 SD decrease in femoral BMD was comparable to a 13–14 year increase in age on the risk of a hip fracture. We conclude that bone mineral measurements made at a variety of skeletal sites can predict the occurrence for at least 8–10 years of moderate trauma fractures of the sort that might be related to osteoporosis.
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openalex_W2010793737 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lee J. Melton, Elizabeth J. Atkinson, W. Michael O’Fallon, Heinz W. Wahner, B. Lawrence Riggs
Journal journal of bone and mineral research : the official journal of the american society for bone and mineral research
Year 1993
DOI
10.1002/jbmr.5650081010
URL
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