Hexokinase as a sugar sensor in higher plants.

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ID: 301759
1997
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Abstract
The mechanisms by which higher plants recognize and respond to sugars are largely unknown. Here, we present evidence that the first enzyme in the hexose assimilation pathway, hexokinase (HXK), acts as a sensor for plant sugar responses. Transgenic Arabidopsis plants expressing antisense hexokinase (AtHXK) genes are sugar hyposensitive, whereas plants overexpressing AtHXK are sugar hypersensitive. The transgenic plants exhibited a wide spectrum of altered sugar responses in seedling development and in gene activation and repression. Furthermore, overexpressing the yeast sugar sensor YHXK2 caused a dominant negative effect by elevating HXK catalytic activity but reducing sugar sensitivity in transgenic plants. The result suggests that HXK is a dual-function enzyme with a distinct regulatory function not interchangeable between plants and yeast.
Reference Key
openalex_W2086968057 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jyan-Chyun Jang, Patricia León, Li Zhou, Jen Sheen
Journal The Plant cell
Year 1997
DOI
10.1105/tpc.9.1.5
URL
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