Effects of obesity and a history of gestational diabetes on the risk of postpartum diabetes and hyperglycemia in Chinese Women: Obesity, GDM and diabetes risk.

Clicks: 436
ID: 30171
2019
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Abstract
To evaluate the independent or combined effects of gestational diabetes (GDM) and pre-pregnancy and postpartum BMI on the odds of postpartum diabetes and hyperglycemia.The study samples included 1,263 women with prior GDM and 705 women without GDM. Postpartum 1-7 years diabetes was diagnosed by the standard oral glucose tolerance test.The multivariable-adjusted odds ratios among women with prior GDM, compared with those without it, were 7.52 for diabetes and 2.27 for hyperglycemia. The multivariable-adjusted odds ratios at different postpartum BMI levels (<24, 24-27.9, and ≥28 kg/m) were 1.00, 2.80, and 8.08 for diabetes (P<0.001), and 1.00, 2.10, and 4.42 for hyperglycemia (P<0.001), respectively. Women with high body fat (≥31.9%) or abdominal obesity (≥85 cm) had a 2.7-6.9-fold higher odds ratio for diabetes or hyperglycemia. Women with both obesity and prior GDM had the highest risk of diabetes or hyperglycemia compared with non-obese women without GDM. Non-obese women with prior GDM had the same risk of diabetes and hyperglycemia as non-GDM women with obesity. When using Cox regression models, the results were very close to those using logistic regression models.Maternal prior GDM and pre-pregnancy or postpartum obesity contribute equally to postpartum diabetes and hyperglycemia risk.
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fan2019effectsdiabetes Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fan, Yuxin;Li, Weiqin;Liu, Huikun;Wang, Leishen;Zhang, Shuang;Li, Wei;Liu, Hongyan;Leng, Junhong;Shen, Yun;Tuomilehto, Jaakko;Yu, Zhijie;Yang, Xilin;Liu, Ming;Hu, Gang;
Journal Diabetes research and clinical practice
Year 2019
DOI
S0168-8227(19)30819-8
URL
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