MitoZ: a toolkit for animal mitochondrial genome assembly, annotation and visualization

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ID: 301300
2019
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Abstract
Mitochondrial genome (mitogenome) plays important roles in evolutionary and ecological studies. It becomes routine to utilize multiple genes on mitogenome or the entire mitogenomes to investigate phylogeny and biodiversity of focal groups with the onset of High Throughput Sequencing (HTS) technologies. We developed a mitogenome toolkit MitoZ, consisting of independent modules of de novo assembly, findMitoScaf (find Mitochondrial Scaffolds), annotation and visualization, that can generate mitogenome assembly together with annotation and visualization results from HTS raw reads. We evaluated its performance using a total of 50 samples of which mitogenomes are publicly available. The results showed that MitoZ can recover more full-length mitogenomes with higher accuracy compared to the other available mitogenome assemblers. Overall, MitoZ provides a one-click solution to construct the annotated mitogenome from HTS raw data and will facilitate large scale ecological and evolutionary studies. MitoZ is free open source software distributed under GPLv3 license and available at https://github.com/linzhi2013/MitoZ.
Reference Key
openalex_W2950509696 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Guanliang Meng, YY Li, Chentao Yang, Shanlin Liu
Journal Nucleic Acids Research
Year 2019
DOI
10.1093/nar/gkz173
URL
https://academic.oup.com/nar/article-pdf/47/11/e63/28838015/gkz173.pdf
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