Highly prevalent putative quadruplex sequence motifs in human DNA

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ID: 299883
2005
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Abstract
We report here the results of a systematic search for the existence and prevalence of potential intramolecular G-quadruplex forming sequences in the human genome. We have also examined the tendency for particular sequences of 'loop' regions to occur in particular positions with respect to the G-tracts in a quadruplex. Using arithmetic ratio and probability techniques we have discovered frequent and systematic occurrence of certain sequence types, the most prominent being a potential quadruplex containing CCTGT in the first 'loop' position. Being able to highlight types of potential quadruplex sequences in G-rich regions is an important step in searching for biologically relevant sequences and finding their function.
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openalex_W2147643191 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alan K. Todd
Journal Nucleic Acids Research
Year 2005
DOI
10.1093/nar/gki553
URL
https://academic.oup.com/nar/article-pdf/33/9/2901/7127290/gki553.pdf
Keywords Keywords not found

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