Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families

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ID: 299751
2017
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Abstract
The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.
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Authors Ioanna Kalvari, Joanna Argasinska, Natalia Quinones‐Olvera, Eric P. Nawrocki, Elena Rivas, Sean R. Eddy, Alex Bateman, Robert Finn, Anton I. Petrov
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Journal Nucleic Acids Research
Year 2017
DOI
10.1093/nar/gkx1038
URL
https://academic.oup.com/nar/article-pdf/46/D1/D335/23162120/gkx1038.pdf
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